Abstract
Cholangitis and pancreatitis associated with cytomegalovirus (CMV) infection in an immunocompetent patient is reported. Endoscopic retrograde cholangiography performed on a 55-year-old man for evaluation of the cause of jaundice and liver dysfunction revealed a distal focal irregular narrowing of the common bile duct. Microscopic findings of the resected specimen showed chronic cholangitis and CMV pancreatitis. Immunohistochemistry disclosed that epithelial cells in the inflamed bile duct were positive for CMV antigen, which was compatible with CMV cholangitis. Inflammation of the biliary tract or pancreas by CMV has been commonly reported as a complication in immunocompromised patients. Our report appears to be a rare case, but suggests that CMV cholangitis or pancreatitis should be considered in the differential diagnoses of common bile duct stenosis or pancreatitis even in immunocompetent individuals.
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References
A Heininger G Jahn C Engel T Notheisen K Unertl K Hamprecht (2001) ArticleTitleHuman cytomegalovirus infections in nonimmunosuppressed critically ill patients Crit Care Med 29 541–7 Occurrence Handle10.1097/00003246-200103000-00012 Occurrence Handle11373417
F Drago MG Aragone C Lugani A Rebora (2000) ArticleTitleCytomegalovirus infection in normal and immunocompromised humans. A review Dermatology 200 189–95 Occurrence Handle10.1159/000018381 Occurrence Handle10828625
T Ponchon P Gagnon F Berger M Labadie A Liaras A Chavaillon et al. (1995) ArticleTitleValue of endobiliary brush cytology and biopsies for the diagnosis of malignant bile duct stenosis: results of a prospective study Gastrointest Endosc 42 565–72 Occurrence Handle10.1016/S0016-5107(95)70049-8 Occurrence Handle8674929
MG Threlkeld CG Cobbs (1995) Cytomegalovirus GL Mandell JE Bennett R Dolin (Eds) Principles and practice of infectious disease Churchill Livingstone New York
FH Ng TN Chau TC Cheung C Kng SY Wong WF Ng et al. (1999) ArticleTitleCytomegalovirus colitis in individuals without apparent cause of immunodeficiency Dig Dis Sci 44 945–52 Occurrence Handle10.1023/A:1026604529393 Occurrence Handle10235602
H al Mahdy (1998) ArticleTitleCytomegalovirus colitis in immunocompetent individual J Clin Pathol 51 475–6 Occurrence Handle9771450
C Altman P Bedossa E Dussaix C Buffet (1995) ArticleTitleCytomegalovirus infection of esophagus in immunocompetent adult Dig Dis Sci 40 606–8 Occurrence Handle10.1007/BF02064378 Occurrence Handle7895553
MJ Eisenberg B Kaplan (1993) ArticleTitleCytomegalovirus-induced thrombocytopenia in an immunocompetent adult West J Med 158 525–6 Occurrence Handle8393603
TD Morre PA Clement M Pipeleers-Marichal (1996) ArticleTitleCytomegalovirus as precipitating factor of acute bacterial sinusitis in an immunocompetent patient. A case report Acta Otorhinolaryngol Belg 50 37–40 Occurrence Handle8669270
JT van der Meer WL Drew RA Bowden GJ Galasso PD Griffiths DA Jabs et al. (1996) ArticleTitleSummary of the International Consensus Symposium on Advances in the Diagnosis, Treatment and Prophylaxis of Cytomegalovirus Infection Antiviral Res 32 119–40 Occurrence Handle10.1016/S0166-3542(96)01006-6 Occurrence Handle8955508
LJ Burgart (1998) ArticleTitleCholangitis in viral disease Mayo Clin Proc 73 479–82 Occurrence Handle9581593
L Joe AF Ansher FM Gordin (1989) ArticleTitleSevere pancreatitis in an AIDS patient in association with cytomegalovirus infection South Med J 82 1444–5 Occurrence Handle2554512
JP Cella S Gupta (1992) ArticleTitleDiagnosis of cytomegalovirus pancreatitis in AIDS by endoscopic retrograde cholangiopancreaticography N Engl J Med 326 204
I Sakamoto T Shirai T Kamide M Igarashi J Koike A Ito et al. (2002) ArticleTitleCytomegalovirus enterocolitis in an immunocompetent individual J Clin Gastroenterol 34 243–6 Occurrence Handle10.1097/00004836-200203000-00010 Occurrence Handle11873105
WL Drew (1992) ArticleTitleCytomegalovirus infection in patients with AIDS Clin Infect Dis 14 608–15 Occurrence Handle1313313
U Krech (1973) ArticleTitleComplement-fixing antibodies against cytomegalovirus in different parts of the world Bull World Health Organ 49 103–6 Occurrence Handle4363395
BL Dolmatch FC Laing MP Ferderle RB Jeffrey JAID Cello (1987) ArticleTitleS-related cholangitis: radiographic findings in nine patients Radiology 163 313–6 Occurrence Handle3550877
JP Cello (1992) ArticleTitleHuman immunodeficiency virus-associated biliary tract disease Semin Liver Dis 12 213–8 Occurrence Handle1636123
EC Klatt D Shibata (1988) ArticleTitleCytomegalovirus infection in the acquired immunodeficiency syndrome. Clinical and autopsy findings Arch Pathol Lab Med 112 540–4 Occurrence Handle2833874
E Klauber LE Briski R Khatib (1998) ArticleTitleCytomegalovirus colitis in the immunocompetent host: an overview Scand J Infect Dis 30 559–64 Occurrence Handle10.1080/00365549850161098 Occurrence Handle10225382
ES Mocarski (1996) Cytomegalovirus and their replication BN Fields DM Knipe PM Howley TP Monath B Roizman SE Straus (Eds) Virology EditionNumber3rd ed. Lippincott-Raven Philadelphia 2447–92
A Maiorana P Baccarini M Foroni N Bellini F Giusti (2003) ArticleTitleHuman cytomegalovirus infection of the gastrointestinal tract in apparently immunocompetent patients Hum Pathol 34 1331–6 Occurrence Handle10.1016/j.humpath.2003.08.005 Occurrence Handle14691920
P Pfau ML Kochman EE Furth GR Lichtenstein (2001) ArticleTitleCytomegalovirus colitis complicating ulcerative colitis in the steroid-naive patient Am J Gastroenterol 96 895–9 Occurrence Handle10.1111/j.1572-0241.2001.03672.x Occurrence Handle11280572
M Cottone G Pietrosi G Martorana A Casa G Pecoraro L Oliva et al. (2001) ArticleTitlePrevalence of cytomegalovirus infection in severe refractory ulcerative and Crohn's colitis Am J Gastroenterol 96 773–5 Occurrence Handle10.1111/j.1572-0241.2001.03620.x Occurrence Handle11280549
L Beaugerie C Cywiner-Golenzer L Monfort PM Girard F Carbonnel Y Ngo et al. (1997) ArticleTitleDefinition and diagnosis of cytomegalovirus colitis in patients infected by human immunodeficiency virus J Acquir Immune Defic Syndr Hum Retrovirol 14 423–9 Occurrence Handle9170416
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Oku, T., Maeda, M., Waga, E. et al. Cytomegalovirus cholangitis and pancreatitis in an immunocompetent patient. J Gastroenterol 40, 987–992 (2005). https://doi.org/10.1007/s00535-005-1683-z
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DOI: https://doi.org/10.1007/s00535-005-1683-z