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Clinical outcome when left atrial posterior wall box isolation is included as a catheter ablation strategy in patients with persistent atrial fibrillation

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Abstract

Purpose

Isolation of the pulmonary veins alone (PVI) is associated with a 50 to 70 % success rate in paroxysmal atrial fibrillation (AF) but is significantly lower for persistent AF. We sought to evaluate patient outcomes in terms of safety and efficacy when posterior left atrial box isolation is included as a catheter ablation strategy in patients with mainly persistent AF.

Methods

We performed an audit of 100 patients undergoing left atrial (LA) box isolation. Recurrence of arrhythmia was detected by evaluating symptoms and continuous 24 h ECG monitoring at 2, 6 and 12 months post procedure.

Results

Seventy-two patients had persistent AF prior to procedure. Average duration of AF was 5.4 ± 5.2 years. All patients underwent circumferential PVI plus linear posterior LA lines to complete box isolation. At a mean follow-up of 12.5 ± 4.2 months, 75 patients were free from atrial fibrillation, 50.6 % of these were taking no antiarrhythmic medication. Twenty-five patients had recurrence of AF, 84 % of whom had previous persistent AF. The average time to recurrence post procedure was 5.9 ± 4.4 months. Thirteen patients underwent repeat procedures for recurrent AF. There were no adverse events relating to the procedure.

Conclusion

These results suggest that the strategy of left atrial box isolation is safe and effective, worthy of further evaluation in a multicentre registry.

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Authors and Affiliations

  1. Cardiology Department, St Vincent’s University Hospital, Dublin, Ireland

    Louisa O’Neill, Mark Hensey & David Keane

  2. University College Dublin, Dublin, Ireland

    William Nolan

Authors
  1. Louisa O’Neill
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  2. Mark Hensey
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  3. William Nolan
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  4. David Keane
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Correspondence to Louisa O’Neill.

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O’Neill, L., Hensey, M., Nolan, W. et al. Clinical outcome when left atrial posterior wall box isolation is included as a catheter ablation strategy in patients with persistent atrial fibrillation. J Interv Card Electrophysiol 44, 63–70 (2015). https://doi.org/10.1007/s10840-015-0024-2

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  • DOI: https://doi.org/10.1007/s10840-015-0024-2

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