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Characteristics of cerebral perfusion and diffusion associated with crossed cerebellar diaschisis after acute ischemic stroke

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Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Purpose

We aimed to investigate the possible factors associated with the occurrence of crossed cerebellar diaschisis (CCD) at the hyperacute stage of ischemic stroke using whole-brain volume perfusion CT (VPCT) combined with magnetic resonance imaging (MRI).

Materials and methods

We retrospectively analyzed 108 patients with ischemic stroke within 6 h of onset. The VPCT findings of the patients showed a unilateral perfusion deficit in the supratentorial territory. Follow-up MRI examinations were performed within 24 h after onset. The effects of the supratentorial cerebral ischemia, the location distribution, the final infarct volume and the apparent diffusion coefficient (ADC) value on the occurrence and severity of CCD were analyzed.

Results

Among 108 patients with hyperacute cerebral ischemia, 62 (57.4%) demonstrated a contralateral cerebellar perfusion deficit on the VPCT maps. The occurrence of CCD was related to a reduction in cerebral blood volume (CBV) and prolongation of the mean transit time (MTT). Notably, the decrease in the ADC value in the infarct based on follow-up MRI was closely related to the occurrence and severity of CCD.

Conclusion

The occurrence and severity of CCD are related to the degree of low supratentorial perfusion and the decrease in the ADC value of infarct focus.

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Authors and Affiliations

  1. Department of Radiology, Xuanwu Hospital, Capital Medical University, Changchun Street, No. 45, Beijing, 100053, China

    Miao Zhang, Yanxiang Cao, Fang Wu, Cheng Zhao, Kuncheng Li & Jie Lu

  2. Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, 100053, China

    Miao Zhang, Yanxiang Cao, Fang Wu, Cheng Zhao, Kuncheng Li & Jie Lu

  3. Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Changchun Street, No. 45, Beijing, 100053, China

    Jie Lu

  4. Department of Neurology, Xuanwu Hospital, Capital Medical University, Changchun Street, No. 45, Beijing, 100053, China

    Qingfeng Ma

Authors
  1. Miao Zhang
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  2. Yanxiang Cao
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  3. Fang Wu
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  4. Cheng Zhao
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Correspondence to Jie Lu.

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The authors declared that they have no conflicts of interest to this work.

Ethical Statement

The study was conducted with approval from our hospital review board, and the imaging data were obtained from the radiology database of our hospital. Informed consent was not required due to the retrospective nature of the study, but as a clinical routine, all patients signed the informed consent for comparative enhancement examination.

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Zhang, M., Cao, Y., Wu, F. et al. Characteristics of cerebral perfusion and diffusion associated with crossed cerebellar diaschisis after acute ischemic stroke. Jpn J Radiol 38, 126–134 (2020). https://doi.org/10.1007/s11604-019-00898-0

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  • DOI: https://doi.org/10.1007/s11604-019-00898-0

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