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Resolution of inflammation pathways in preeclampsia—a narrative review

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Abstract

Preeclampsia (PE) is one of the leading causes of maternal morbidity and mortality worldwide. This disease is believed to occur in two stages with placental dysfunction in early pregnancy leading to maternal clinical findings after 20 weeks of gestation, as consequence of systemic inflammation, oxidative stress, and endothelial dysfunction. Much evidence suggests that PE women display an overshooting inflammatory response throughout pregnancy due to an unbalanced regulation of innate and adaptive immune responses. Recently, it has been suggested that dysregulation of endogenous protective pathways might be associated with PE etiopathogenesis. Resolution of inflammation is an active process coordinated by mediators from diverse nature that regulate key cellular events to restore tissue homeostasis. Inadequate or insufficient resolution of inflammation is believed to play an important role in the development of chronic inflammatory diseases, like PE. In this narrative review, we discuss possible pro-resolution pathways that might be compromised in PE women, which could be targets to novel therapeutic strategies in this disease.

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Acknowledgments

The authors are grateful to Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Research Fellowship.

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Authors and Affiliations

  1. Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil

    Luiza Oliveira Perucci, Luci Maria Dusse, Karina Braga Gomes & Lirlândia Pires Sousa

  2. Programa de Pós-Graduação em Análises Clínicas e Toxicológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil

    Luiza Oliveira Perucci, Luci Maria Dusse, Karina Braga Gomes & Lirlândia Pires Sousa

  3. Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, 30130-100, Brazil

    Mário Dias Corrêa

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  1. Luiza Oliveira Perucci
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  2. Mário Dias Corrêa
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  3. Luci Maria Dusse
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  4. Karina Braga Gomes
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  5. Lirlândia Pires Sousa
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Correspondence to Lirlândia Pires Sousa.

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Funding

This study was funded by Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG; APQ-03318-15), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; Research Fellowship), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES; Ph.D. scholarship).

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The authors declare that they have no conflict of interest.

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Perucci, L.O., Corrêa, M.D., Dusse, L.M. et al. Resolution of inflammation pathways in preeclampsia—a narrative review. Immunol Res 65, 774–789 (2017). https://doi.org/10.1007/s12026-017-8921-3

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