Technical and clinical experience with Protein A Immunoadsorption columns
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Cited by (41)
Safety and efficacy of immunoadsorption versus plasma exchange in steroid-refractory relapse of multiple sclerosis and clinically isolated syndrome: A randomised, parallel-group, controlled trial
2019, EClinicalMedicineCitation Excerpt :The processed plasma is returned to the patient, therefore no volume replacement solution is needed. IA has repeatedly been described as a safe and well-tolerated procedure [9–11]. Furthermore, studies investigating other auto-immune neurological indications like myasthenia gravis suggest that side effects might be significantly reduced in IA compared to PE [12,13].
Comparing the efficacy of three techniques to reduce isoagglutinin titers in AB0 incompatible kidney transplant recipients
2017, Atherosclerosis SupplementsCitation Excerpt :We therefore started using unspecific peptide immune adsorbers, which were previously described to bind IgG very effectively. Their capacity to eliminate IgM, however, is only moderate [2]. In cases with persistent high IgM titers we thus combined IA for a single session with membrane filtration (IAc) performed with a polysulfone filter enhanced for lipoprotein filtration.
Renal Transplantation Across HLA and ABO Barriers
2017, Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine EraInhibitory effects of calf thymus DNA on metabolism activity of CYP450 enzyme in human liver microsomes
2014, Drug Metabolism and PharmacokineticsPharmacokinetics study of calf thymus DNA in rats and beagle dogs with <sup>3</sup>H-labeling and tracing method
2014, Journal of Pharmaceutical and Biomedical AnalysisImmunoadsorption in steroid-refractory multiple sclerosis
2013, Atherosclerosis SupplementsCitation Excerpt :However regarding a higher procedural safety of IA compared to PE, this possible conclusion was limited by the small number of patients and treatments in this study [16]. Depending on adsorber matrix and processed plasma volume, IA seems to be more effective in eliminating autoantibodies than PE [17,18], although there are also controversial data [16,19]. However, keeping in mind that the clinical course in MS does not correlate with autoantibody titers [8,9], responsiveness of steroid-refractory relapses of MS to apheresis therapy should unlikely depend on antibody clearance rates alone.