Idiopathic thrombocytopenic purpura in childhood†
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Cited by (123)
To Treat or Not To Treat-From Guidelines to Individualized Patient Management
2013, Seminars in HematologyChildhood Immune Thrombocytopenic Purpura: Diagnosis and Management
2010, Hematology/Oncology Clinics of North AmericaChronic Immune Thrombocytopenia in Children: Epidemiology and Clinical Presentation
2009, Hematology/Oncology Clinics of North AmericaCitation Excerpt :Skin findings of bruising and petechiae can be extensive, but many children with ITP have only minimal evidence of bleeding despite profound thrombocytopenia.31,32 Typical bleeding manifestations include purpura, petechiae, epistaxis, hematuria, and menorrhagia (in teenage girls).29–31,33 The physical examination is usually normal otherwise.
Childhood Immune Thrombocytopenic Purpura: Diagnosis and Management
2008, Pediatric Clinics of North AmericaThe pros and cons of drug therapy for immune thrombocytopenic purpura in children
2004, Hematology/Oncology Clinics of North AmericaImmune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro
2003, BloodCitation Excerpt :The thrombocytopenia of this disorder is associated with autoantibodies that are directed against various platelet membrane receptors, including platelet glycoproteins such as glycoprotein IIb/IIIa (GPIIb/IIIa) or GPIb/IX complexes.4-7 Binding of autoantibodies to these target antigens eventually results in platelet destruction by the reticuloendothelial system.1,2 Since the target antigens of these autoantibodies are present on both platelets and their precursors, megakaryocytes, it is possible that megakaryocytopoiesis and thrombopoiesis are also impaired during ITP,8-10 which could further aggravate the thrombocytopenia caused initially by increased peripheral destruction of platelets.
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Supported in part by United States PublicHealth Service Research Grant AM 02940 from the National Institute of Allergy and Metabolic Diseases and in part by a grant from the Children's Leukemia Foundation.
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Address, Child Research Center of Michigan,660 Frederick Street, Detroit 2, Mich.