Idiopathic thrombocytopenic purpura in childhood

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References (24)

  • WalkerJ. et al.

    Idiopathic thrombocytopenic purpura in childhood

    Arch. Dis. Childhood

    (1961)
  • NewtonW.A. et al.

    Idiopathic thrombopenic purpura in childhood

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  • Cited by (123)

    • Childhood Immune Thrombocytopenic Purpura: Diagnosis and Management

      2010, Hematology/Oncology Clinics of North America
    • Chronic Immune Thrombocytopenia in Children: Epidemiology and Clinical Presentation

      2009, Hematology/Oncology Clinics of North America
      Citation Excerpt :

      Skin findings of bruising and petechiae can be extensive, but many children with ITP have only minimal evidence of bleeding despite profound thrombocytopenia.31,32 Typical bleeding manifestations include purpura, petechiae, epistaxis, hematuria, and menorrhagia (in teenage girls).29–31,33 The physical examination is usually normal otherwise.

    • Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro

      2003, Blood
      Citation Excerpt :

      The thrombocytopenia of this disorder is associated with autoantibodies that are directed against various platelet membrane receptors, including platelet glycoproteins such as glycoprotein IIb/IIIa (GPIIb/IIIa) or GPIb/IX complexes.4-7 Binding of autoantibodies to these target antigens eventually results in platelet destruction by the reticuloendothelial system.1,2 Since the target antigens of these autoantibodies are present on both platelets and their precursors, megakaryocytes, it is possible that megakaryocytopoiesis and thrombopoiesis are also impaired during ITP,8-10 which could further aggravate the thrombocytopenia caused initially by increased peripheral destruction of platelets.

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    Supported in part by United States PublicHealth Service Research Grant AM 02940 from the National Institute of Allergy and Metabolic Diseases and in part by a grant from the Children's Leukemia Foundation.

    *

    Address, Child Research Center of Michigan,660 Frederick Street, Detroit 2, Mich.

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