Clinical investigationsOxygen uptake efficiency slope, a new submaximal parameter in evaluating exercise capacity in chronic heart failure patients
Section snippets
Study population
The study population consisted of 80 consecutive patients who visited the outpatient clinic between January and July 2003 prior to their enrollment in a cardiac rehabilitation program. All patients performed a maximal cardiopulmonary exercise test with a respiratory exchange ratio (RERmax) >1.10 and were free of exercise-limiting comorbidities, such as cerebrovascular disease, musculoskeletal impairment, or vascular disease of the lower extremities. Patients were divided into 2 groups according
Baseline clinical and demographic characteristics
Characteristics of patients with and without LV dysfunction are detailed in Table I. By definition group A patients had a lower EF (P < .01) and a higher New York Heart Association (NYHA) class (P < .01). No difference in age, body mass index, or sex was noted between the groups. The incidence of ischemic heart disease was significantly higher in group B patients (P < .01). No difference was noted between both groups in the percentage of patients taking angiotensin-converting enzyme inhibitors
Discussion
Although peakVO2 is considered as a gold standard for stratification of heart failure patients, its use is limited by conditioning status, patient motivation, skeletal muscle structure, pulmonary function, and hemoglobin level. Because of all these limitations, some patients will not achieve their anaerobic threshold during exercise and peakVO2 can not be accurately assessed. To overcome these limitations, submaximal metabolic parameters have been proposed as surrogates to estimate exercise
References (22)
- et al.
Peak exercise consumption in chronic heart failuretoward efficient use in the individual patient
J Am Coll Cardiol
(1998) - et al.
Prognostic value of cardiopulmonary exercise testing using percent achieved of predicted peak oxygen uptake for patients with ischemic and dilated cardiomyopathy
J Am Coll Cardiol
(1996) Optimal candidates for heart transplantationis 14 the magic number?
J Am Coll Cardiol
(1995)- et al.
Ventilatory threshold during exercise in patients with mild to moderate heart failuredetermination, relation with lactate threshold and reproducibility
Int J Cardiol
(1991) - et al.
Oxygen uptake efficiency slopea new index of cardiorespiratory functional reserve derived from the relation between oxygen uptake and minute ventilation during incremental exercise
J Am Coll Cardiol
(1996) - et al.
Oxygen uptake efficiency slopeAn index of exercise performance and cardiopulmonary reserve requiring only submaximal exercise
J Am Coll Cardiol
(2000) - et al.
Ventilatory threshold during exercise in patients with mild to moderate chronic heart failuredetermination, relation with lactate threshold and reproducibility
Int J Cardiol
(1991) - et al.
The ventilatory thresholdquantitative analysis of reproducibility and relation to arterial lactate concentration in normal subjects and in patients with chronic congestive heart failure
Am J Cardiol
(1988) - et al.
Anaerobic threshold detection in patients with congestive heart failure
Am J Cardiol
(1992) - et al.
Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure
Circulation
(1991)
The role of exercise testing and gas exchange measurement in the prognostic assessment of patients with heart failure
Curr Opin Cardiol
Cited by (109)
Oxygen Uptake Efficiency Slope at a Glance: A Fascinating Index Carrying Unsolved Questions
2023, American Journal of CardiologyOxygen Uptake Efficiency Slope and Prognosis in Heart Failure With Reduced Ejection Fraction
2023, American Journal of CardiologyOxygen uptake efficiency slope: A submaximal test evaluation tool that provides cardiopulmonary reserve data in individuals with Parkinson's disease
2021, Brazilian Journal of Physical TherapyCitation Excerpt :Regardless of these limitations, this study shows an alternative and feasible measurement which should be incorporated into clinical practice. Despite VO2peak being considered a gold standard measurement in CRF assessment, its use is limited for several factors such as patient's motivation, physical fitness, examiner experience, skeletal muscle structure, and pulmonary function.51,52 All of these factors could influence its accuracy.
Cardiopulmonary exercise testing in chronic heart failure patients treated with beta-blockers: Still a valid prognostic tool
2020, International Journal of CardiologyCitation Excerpt :Moreover, duration of follow-up was different [8,11–19,21–23], as were the events accrued during the follow-up; in some studies, non-urgent HT, left ventricular device implantation [19] and HF hospitalization [22] were also considered. Finally, the percentage of events (normalized for the duration of follow-up) was also higher, in some experiences [8,12,13,15–23]. The selection of peak VO2%, peak SBP, EOV and their combination was related both to the patients selected (eligibility criteria), to the effects of BBs on exercise performance and to our control for statistical pitfalls (e.g. after adjustment for collinearity, peak VO2 was excluded).
Relation of Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease to Left Ventricular Diastolic Function and Exercise Tolerance
2019, American Journal of Cardiology