Clinical InvestigationCongestive Heart FailurePrognostic value of heart rate recovery in patients with heart failure
Section snippets
Methods
Eighty-seven subjects, assessed between May 13, 1997, and October 18, 2004, were included in the study. The subjects were tested and followed by the HF program at the Medical College of Virginia in Richmond. All subjects underwent CPX on an outpatient basis and were instructed to maintain their normal pharmacological regimen. None of the subjects were participating in a cardiac rehabilitation or secondary prevention program at the time of testing. The exercise tests were conducted as part of
Results
Termination of exercise was due to volitional fatigue for all subjects. No subject demonstrated an abnormal physiological response to exercise (ECG signs of ischemia, new onset of arrhythmias, or excessive hypotensive/hypertensive response) warranting test termination before subject request.
The mean peak RER, peak Vo2, VE/Vco2 slope, and HRR1 were 1.06 (±0.11), 14.8 (±4.7) mL · kg−1 · min−1, 36.6 (±8.6), and 11.0 (±10.4) beat/min, respectively. HRR1 was significantly correlated with peak Vo2 (r
Discussion
The results of the present study indicate that HRR provides valuable prognostic information in patients diagnosed with HF. This finding is consistent with previous investigations demonstrating the ability of HRR to predict adverse events in populations other than HF.17, 18, 19, 20 To our knowledge, the current study is the first to be conducted in subjects with compensated HF. Importantly, HRR1 appears to outperform peak Vo2, LVEF, and HF etiology in predicting risk of death or hospitalization
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