ResearchBasic science: ObstetricsHuman cytomegalovirus reinfection is associated with intrauterine transmission in a highly cytomegalovirus-immune maternal population
Section snippets
Study population and design
Forty mothers of infants with congenital CMV infection and 109 mothers of uninfected infants were enrolled in the study. These subjects were selected from 7848 mothers of 8047 infants born at 2 maternity hospitals in the municipality of Ribeirão Preto, Brazil, whose infants were screened (85% all live births) for congenital CMV infection (1.1% rate of congenital CMV infection).8, 17 Among 84 mothers of 87 infants (3 twins) who were identified with congenital CMV infection, 58 (69%) were
Results
Mothers of infected and uninfected infants did not differ in age (median, 20 vs 22 years), years of formal education (median, 8 years vs 9 years), exposure to children <2 years of age (14/40 vs 23/109), age of sexual debut (median, 15 vs 16 years), or number of sexual partners (median, 2). When exposure to young children was extended to include children ≤3 years, significantly more mothers of infected infants cared for young children (23/40 vs 37/109; P = .01).
The median gestational age at
Comment
Women from this region of Brazil with evidence of infection with multiple CMV strains, including women acquiring new virus strains during pregnancy, were more likely to deliver congenitally infected infants than women who lacked serologic evidence of infection with multiple CMV strains. These findings provided support for the hypothesis that reinfections with new virus strains were responsible for a significant number of congenital CMV infections in offspring of women from this highly
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Cite this article as: Yamamoto AY, Mussi-Pinhata MM, Boppana SB, et al. Human cytomegalovirus reinfection is associated with intrauterine transmission in a highly cytomegalovirus-immune maternal population. Am J Obstet Gynecol 2010;202:297.e1-8.
This work was supported by grants from the National Institutes of Health (NIAID AI 49537; Fogarty International Center, R03 TW006480, to W.J.B., and NIDCDDC04162 to S.B.B.) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Brazil, process no. 02/04166-6.
Reprints not available from the authors.