Congenital heart diseaseEffect of Beta Blockers (Carvedilol or Metoprolol XL) in Patients With Transposition of Great Arteries and Dysfunction of the Systemic Right Ventricle
Section snippets
Methods and Results
We carried out a retrospective analysis of the medical records of patients who had systemic RV dysfunction late after atrial inflow correction for d-TGA. Sixty patients were included, 31 of whom received β blockers. Baseline demographics are listed in Table 1. Functional classification before and after therapy with β blockers was assessed using New York Heart Association (NYHA) functional class. All available echocardiograms were reviewed. Systemic RV ejection fractions were evaluated by visual
Discussion
In the present study, we found that β blockers resulted in improvement in NYHA functional class in patients with d-TGA and systemic RV dysfunction. This improvement was found to be more significant in patients with pacemakers who received higher maintenance doses of β blockers. We could not demonstrate any significant effect of β blockers on the RV ejection fraction, RV end-diastolic area, or the degree of tricuspid regurgitation. However, untreated patients showed increased RV end-diastolic
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