AJM onlineClinical communication to the EditorCholangiocarcinoma Presenting as Metastases to the Cervical Spine
Section snippets
Discussion
In this case report, we present a case of metastatic cholangiocarcinoma to the cervical spine. To our knowledge, this is the first published report of cervical spinal metastasis as the initial presentation of cholangiocarcinoma.
Cholangiocarcinoma most commonly advances locally and regionally by invading lymph nodes, but distant metastasis to cervical lymph nodes in the head and neck have been described.3, 4 In addition, there is a single published case report describing cholangiocarcinoma
References (6)
- et al.
Metastatic cholangiocarcinoma with an occult primary
Clin Oncol (R Coll Radiol)
(1995) Spinal cord compression from epidural metastases
N Engl J Med
(1992)- et al.
Spinal metastases with neurological manifestationsReview of 600 cases
J Neurosurg
(1983)
Cited by (11)
Cholangiocarcinoma with spinal metastasis: Single center survival analysis
2017, Journal of Clinical NeuroscienceCitation Excerpt :Cholangiocarcinoma (CCA) is an epithelial cell malignancy arising from various locations within the biliary tree, presenting the marker for cholangiocyte differentiation [1]. CCA tends to progress locally and regionally by spreading through the lymphatic system with metastases through the venous and lymphatic systems [2–5]. The incidence of CCA varies worldwide and the highest incidence is in Khon Kaen province, Thailand, where the incidence is 44.3 and 17.6 per 100,000 males and females, respectively [6].
Non-hepatocellular carcinoma spinal metastases
2016, Journal of Clinical NeuroscienceCitation Excerpt :A recent literature review of 40 adult patients with hepatoblastoma revealed an overall median survival time of 4 months, and a 1 year survival rate of 29.6% [12]. Each of these tumors has a poor prognosis with few reports in the literature of metastases from these neoplasms to any location, and only a minority of these reports in the known literature includes metastases to the skeletal system [7,10,13,14]. Although the existing literature on clinical outcomes following a diagnosis of non-hepatocellular carcinoma metastasis to the spine is limited, it is expected that an increased number of patients will present with a diagnosis of metastatic disease or the sequelae of these malignancies in the future.
Distal fibula metastasis of cholangiocarcinoma
2013, Journal of Foot and Ankle SurgeryAberrant pattern of the cytokeratin 7/cytokeratin 20 immunophenotype in colorectal adenocarcinomas with BRAF mutations
2012, Pathology Research and PracticeCitation Excerpt :Bayrak et al. [1] recently suggested that 17.3% of colorectal adenocarcinomas (CRC) expressed cytokeratin 7 (CK7) and 18.9% of cases did not express cytokeratin 20 (CK20), although most authors admit that CK20 is of great importance in the differentiation of colonic metastases from other metastatic tumors like lung, bladder, breast carcinomas and cholangiocarcinomas [4,5,8].
Epidemiological and pathological characteristics of spinal metastases from gastrointestinal cancers – a series of 40 cases
2023, Romanian Journal of Morphology and EmbryologyA single-center 10-year retrospective study of clinical features and surgical treatment of spinal metastasis from cholangiocarcinoma
2021, Annals of Palliative Medicine
Funding: None.
Conflict of Interest: None of the authors have any conflicts of interest associated with the work presented in this manuscript.
Authorship: All listed authors had access to the data used in the paper and contributed to the writing of the manuscript.