Journal of Stroke and Cerebrovascular Diseases
Case ReportCerebral Infarct in a Patient with a History of Systemic Arterial and Venous Thrombosis from Essential Thrombocythemia
Section snippets
Case Report
A 46-year-old man was admitted because of the sudden development of a tingling sensation in his left face, arm, and leg. The patient had first been seen at our hospital 8 years earlier because of abdominal pain. A computed tomographic scan of the abdomen revealed multiple splenic infarctions and thrombosis in the superior mesenteric, splenic, and portal veins (Fig 1). Repeated blood tests revealed high platelet counts (1,000,000/μL). A diagnosis of ET was made based on the results of a bone
Discussion
Our patient experienced 3 major thrombotic events—splenic infarction with splanchnic venous thrombosis, myocardial infarction, and cerebral infarction—over an 8-year period. He had 2 additional arterial thrombotic events after the occurrence of the first venous thrombosis. A recent report found that both arterial and venous thrombotic complications in ET were extremely rare (7/891; 0.78%) after a median follow-up of 6.2 years.2 In addition, recurrent thrombosis involved 3 different sites: the
References (4)
- et al.
Risk factors for arterial and venous thrombosis in WHO-defined essential thrombocythemia: An international study of 891 patients
Blood
(2011) - et al.
Major vascular complications in essential thrombocythemia: A study of the predictive factors in a series of 148 patients
Leukemia
(1999)
Cited by (7)
Cerebrovascular events as presenting manifestations of Myeloproliferative Neoplasm
2016, Revue NeurologiqueCitation Excerpt :Early ET diagnosis and treatment can prevent cerebrovascular events [22]. Cytoreductive treatment (hydroxyurea as a first-line treatment) and low-dose aspirin are preferentially used to prevent thrombosis and can reduce the risk by approximately 50% in ET patients [25–27]. Hemorrhages rarely occur (< 10% of all patients with ET) and, surprisingly, are related to higher platelet counts [28].
Splenic Infarct as the Presenting Manifestation of Essential Thrombocythemia
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