Original
CARDIOVASCULAR EFFECTS OF 2-(O-CHLOROPHENYL)-2-METHYLAMINOCYCLOHEXANONE (CI-581)* IN RATS

https://doi.org/10.1093/bja/41.5.391Get rights and content
Under an Elsevier user license
open archive

SUMMARY

2-(O-chlorophenyl)-2-methylaminocyclohexanone (CI-581), a derivative of phencyclidine, was shown to depress the cardiovascular system in conscious rats and in rats anaesthetized with pentobarbitone and urethane. In pithed animals, however, there was a substantial rise in blood pressure, suggesting that CI-581 may act on the central cardiovascular regulatory mechanisms. The pressor response to CI-581 in pithed animals was considerably reduced by phenoxybenzamine and phenotolamine. In reserpinized animals, the pressor response to CI-581 was abolished but could be restored by infusions with noradrenaline. Thus, CI-581 may act indirectly by releasing catecholamines from peripheral stores. In adrenalectomized rats, the increase in blood pressure elicted by CI-581 was abolished by pre-treatment with reserpine. The data indicate that the peripheral release of catecholamines by CI-581 may be derived from more than one storage site.

Cited by (0)

*

The approved name is ketamine.