ArticlesGranular Cell Tumor of the Esophagus: Report of Five Cases and Review of the Literature
Section snippets
Methods and Case Reports
This study represents a retrospective review of medical records, endoscopic, pathologic, and radiologic databases of all the consecutive patients who underwent an endoscopic procedure at VA Medical Center, Memphis, Tennessee, from Feb 2001 to June 2005. During this review, from a total of 4556 upper endoscopies of the GI tract, 5 cases of GCT were identified. This diagnosis constituted only 0.1% of all patients who underwent endoscopy of the upper GI tract at our institution during that period.
Discussion
Granular cell tumors are uncommon and typically benign. Most of these neoplasms are usually located in the head and neck region, and only 4% to 6% of granular cell tumors are located in the GI tract6., 7. 1/3 of which in the esophagus1., 8., 9., 10., 11. followed by the large intestine, in which GCT usually occurs in the anorectal area and ascending colon.12 GCTs are usually solitary lesion localized in distal esophagus; however, multifocal GCTs have been reported as well.13 Although in general
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2014, Annals of Thoracic SurgeryCitation Excerpt :Small (less than 1 cm in diameter) and asymptomatic neoplasms with benign clinical course indicate conservative approach with only regular endoscopic and EUS follow-up, thus avoiding potential surgical or endoscopic resection complications [5, 11, 19]; whereas endoscopic or surgical resection should be performed for tumors sized 1 cm or greater, rapid recent growth, suspicion of malignancy, or transmural infiltration, or producing symptoms such as dysphagia [11, 19, 26]. Endoscopic resection includes EMR and submucosal tunnel endoscopic resection; EMR is applied in patients with lesions 2 cm or less in diameter and nonattachment to the muscularis propria [14], and submucosal tunnel endoscopic resection is applied in patients with lesions ranging from 2 cm to 3 cm and located in submucosa. When direct EMR is difficult to perform, epinephrine or a similar solution is injected into submucosa to separate the superficial mucosa from muscularis propria, raising the neoplasm, to avoid bleeding and perforation during the procedure.
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