Does wound irrigation with triamcinolone reduce pain after surgery to the lumbar spine?

Br J Anaesth. 2000 Jun;84(6):731-4. doi: 10.1093/oxfordjournals.bja.a013583.

Abstract

This prospective, randomized study compared postoperative pain scores, morphine consumption and length of stay in 95 adults who underwent elective lumbar spine surgery via a posterior incision. Immediately prior to closure the wound was irrigated with triamcinolone 40, 20 or 0 mg. Visual analogue scale pain scores at 24 h after surgery were median 12 (interquartile range 3-24), 15 (6-34) and 33 (20-59) mm for patients receiving triamcinolone 40, 20 mg or no steroid, respectively (P < 0.0005, Kruskal-Wallis test). Total morphine usage after 24 h was 26 (21-39), 27 (17-43) and 43 (27-73) mg for the same groups (P < 0.001, Kruskal-Wallis test). The proportion of patients discharged from hospital on the first day after surgery was 83.9, 77.4 and 54.8% for patients receiving triamcinolone 40, 20 mg and no steroid, respectively (P < 0.028, chi-squared test). Extra-dural triamcinolone reduces pain after lumbar spine surgery and reduces time to discharge from hospital.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Analgesics, Opioid / administration & dosage
  • Analysis of Variance
  • Anti-Inflammatory Agents / therapeutic use*
  • Dose-Response Relationship, Drug
  • Female
  • Glucocorticoids / therapeutic use*
  • Humans
  • Length of Stay
  • Lumbar Vertebrae / surgery*
  • Male
  • Middle Aged
  • Morphine / administration & dosage
  • Pain Measurement
  • Pain, Postoperative / prevention & control*
  • Prospective Studies
  • Spinal Diseases / surgery*
  • Therapeutic Irrigation
  • Triamcinolone / therapeutic use*

Substances

  • Analgesics, Opioid
  • Anti-Inflammatory Agents
  • Glucocorticoids
  • Triamcinolone
  • Morphine