RETRACTED: miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation

Cancer Cell. 2009 Dec 8;16(6):498-509. doi: 10.1016/j.ccr.2009.10.014.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the editors. This article was published on December 8, 2009. In November 2021, The Ohio State University notified the Cancer Cell editors that this article contains ten instances of plagiarized text; that Figures 1G, 5B, 5E, 7D, and 7F were falsified; and that part of Figure 1G in the article is the same as part of Figure 1B in another article that was later retracted (Garofalo et al., 2008, PLOS One 3, e4070, https://doi.org/10.1371/journal.pone.0004070). The university recommended the editors correct or retract the article. Given the extent and severity of these issues, the editors are retracting the article. S.-S. S. agrees with the retraction, and M.G., G.D.L., G.N., F.P., P.S., P.G., G.C., and C.M.C. disagree with the retraction; all other authors couldn't be reached or didn't respond.

Publication types

  • Research Support, Non-U.S. Gov't
  • Retracted Publication

MeSH terms

  • Carcinoma, Non-Small-Cell Lung / pathology
  • Down-Regulation / physiology*
  • Humans
  • Liver Neoplasms / pathology
  • MicroRNAs / physiology*
  • PTEN Phosphohydrolase / physiology*
  • TNF-Related Apoptosis-Inducing Ligand / physiology*
  • Tissue Inhibitor of Metalloproteinase-3 / physiology*

Substances

  • MIRN221 microRNA, human
  • MIRN222 microRNA, human
  • MicroRNAs
  • TIMP3 protein, human
  • TNF-Related Apoptosis-Inducing Ligand
  • TNFSF10 protein, human
  • Tissue Inhibitor of Metalloproteinase-3
  • PTEN Phosphohydrolase
  • PTEN protein, human