Secondary amyloidosis in a patient with long duration Crohn's disease treated with infliximab

BioDrugs. 2010 Dec 14:24 Suppl 1:15-7. doi: 10.2165/11586250-000000000-00000.

Abstract

Systemic AA amyloidosis is a serious complication of many chronic inflammatory disorders. Its association with Crohn's disease implies that the inflammatory burden is high enough for amyloid fibrils to form deposits in tissues. A case is presented in which this complication occurred while the patient was clinically well, with biological and endoscopic markers showing an inactive or mildly active disease under anti-tumor necrosis factor alpha therapy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amyloid / metabolism
  • Amyloidosis / etiology*
  • Amyloidosis / pathology
  • Anti-Inflammatory Agents / therapeutic use*
  • Antibodies, Monoclonal / therapeutic use*
  • Biomarkers / metabolism
  • Crohn Disease / complications*
  • Crohn Disease / drug therapy*
  • Humans
  • Infliximab
  • Male
  • Time Factors
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*

Substances

  • Amyloid
  • Anti-Inflammatory Agents
  • Antibodies, Monoclonal
  • Biomarkers
  • Tumor Necrosis Factor-alpha
  • Infliximab