Abstract
Systemic AA amyloidosis is a serious complication of many chronic inflammatory disorders. Its association with Crohn's disease implies that the inflammatory burden is high enough for amyloid fibrils to form deposits in tissues. A case is presented in which this complication occurred while the patient was clinically well, with biological and endoscopic markers showing an inactive or mildly active disease under anti-tumor necrosis factor alpha therapy.
MeSH terms
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Adult
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Amyloid / metabolism
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Amyloidosis / etiology*
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Amyloidosis / pathology
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Anti-Inflammatory Agents / therapeutic use*
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Antibodies, Monoclonal / therapeutic use*
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Biomarkers / metabolism
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Crohn Disease / complications*
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Crohn Disease / drug therapy*
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Humans
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Infliximab
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Male
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Time Factors
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Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Substances
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Amyloid
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Anti-Inflammatory Agents
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Antibodies, Monoclonal
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Biomarkers
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Tumor Necrosis Factor-alpha
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Infliximab