… D19/D19 mutant mice showed lower insulin levels than db/db, consistent with b cell deficits
… Given the age-dependent deficits in pancreatic b cell proliferation and insulin secretion in …

… Both LLC and cisplatin induced a significant decrease in body weight compared with control
animals, whereas ghrelin administration prevented these changes (Figure 1A and B). Lean …

Cachexia, defined as an involuntary weight loss ≥5%, is a serious and dose-limiting side
effect of chemotherapy that decreases survival in cancer patients. Alterations in lipid …

… Animal studies with induced CHF showed that GH activates nuclear factor kappa-B (NF-κB),
promoting increased levels of antiapoptotic factor Bcl-2. Simultaneously, caspases and bax …

… 1B also shows that these proteins were more abundant in the membrane-associated,
EGTA-solubilized extracts than in the culture supernatants (Fig. 1B, lanes 2 and 3 versus lanes 4 …

Leukocyte adhesion to vascular endothelium and platelets is an early step in the acute
inflammatory response. The initial process is mediated through P-selectin glycoprotein ligand-1 (…

The present analyses were done to define the role of fetuin-A (Fet) in mammary tumorigenesis
using the polyoma middle T antigen (PyMT) transgenic mouse model. We crossed Fet-…

Immune thrombotic thrombocytopenic purpura (iTTP) is primarily caused by immunoglobulin
G (IgG)–type autoantibodies that bind and inhibit plasma ADAMTS13 activity and/or …

… Dr Guillory was supported by a training grant from the NIA (T32AG000183). We thank the
University of Washington DERC (P30 DK017047) and NORC (P30 DK035816), Vanderbilt …

… Dr Guillory was supported by a training grant from the NIA (T32AG000183). Dr Chen and
Luo are supported by National Natural Science Foundation of China (81072262, 81372944). …