It has now been demonstrated that the μ, δ 1 , δ 2 , and κ 1 opioid receptor (OR) agonists
represent the most promising group of opioids for the creation of drugs enhancing cardiac …

It has been documented that Ca 2+ overload and increased production of reactive oxygen
species play a significant role in reperfusion injury (RI) of cardiomyocytes. Ischemia/…

Two series of experiments were performed in the isolated perfused rat heart to determine
the role of κ- and δ-opioid receptors (OR) in cardioprotection of ischemic preconditioning (IP). …

Background The use of percutaneous coronary intervention (PCI) in patients with ST‐segment
elevation myocardial infarction (STEMI) is associated with a mortality rate of 5%–7%. It is …

This study was designed to investigate whether Resveratrol (Res) could be a prophylactic
factor in the prevention of I/R injury and to shed light on its underlying mechanism. Primary …

Macrophages are essential for wound repair after myocardial infarction (MI). CD226, a member
of immunoglobulin superfamily, is expressed on inflammatory monocytes, however, the …

Evidence has indicated that resveratrol (Res) produces vasorelaxation and may decrease
the coronary heart disease mortality. However, several pathways involved in the mechanism …

To test the hypothesis that heat-shock proteins (HSPs) mediate delayed cardioprotection of
prior κ-opioid receptor (κ-OR) stimulation, we first correlated cellular injury and viability with …

BACKGROUND AND AIMS: It remains unclear whether U50488H (a selective κ-opioid receptor
agonist) produces anti-apoptotic effect during ischemia and reperfusion (I/R). Therefore, …

The aim of the present study was to determine whether U50,488H (a selective κ-opioid receptor
agonist) inhibits cardiac hypertrophy and fibrosis induced by β-adrenoceptor stimulation …