The ability to summarize observations using explanatory and predictive theories is the
greatest strength of modern science. A theoretical framework is perceived as particularly …

While single-cell gene expression experiments present new challenges for data processing,
the cell-to-cell variability observed also reveals statistical relationships that can be used by …

Approximate Bayesian computation (ABC) methods can be used to evaluate posterior
distributions without having to calculate likelihoods. In this paper, we discuss and apply an ABC …

Motivation: Computer simulations have become an important tool across the biomedical
sciences and beyond. For many important problems several different models or hypotheses …

We present a novel and simple method to numerically calculate Fisher information matrices
for stochastic chemical kinetics models. The linear noise approximation is used to derive …

Background Rhinovirus infection is a major cause of asthma exacerbations. Objectives We
studied nasal and bronchial mucosal inflammatory responses during experimental rhinovirus-…

After the completion of the human and other genome projects it emerged that the number of
genes in organisms as diverse as fruit flies, nematodes, and humans does not reflect our …

Candida species are the most common cause of opportunistic fungal infection worldwide.
Here we report the genome sequences of six Candida species and compare these and related …

Most studies of networks have only looked at small subsets of the true network. Here, we
discuss the sampling properties of a network's degree distribution under the most parsimonious …

Kuru is an acquired prion disease largely restricted to the Fore linguistic group of the Papua
New Guinea Highlands, which was transmitted during endocannibalistic feasts. …