User profiles for Rong Fan

Rong Fan

Harold Hodgkinson Professor of Biomedical Engineering, Yale University
Verified email at yale.edu
Cited by 19720

Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood

R Fan, O Vermesh, A Srivastava, BKH Yen, L Qin… - Nature …, 2008 - nature.com
As the tissue that contains the largest representation of the human proteome 1 , blood is the
most important fluid for clinical diagnostics 2 , 3 , 4 . However, although changes of plasma …

[PDF][PDF] High-spatial-resolution multi-omics sequencing via deterministic barcoding in tissue

…, Z Bai, E Norris, A Pan, J Li, Y Xiao, S Halene, R Fan - Cell, 2020 - cell.com
We present deterministic barcoding in tissue for spatial omics sequencing (DBiT-seq) for co-mapping
of mRNAs and proteins in a formaldehyde-fixed tissue slide via next-generation …

Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells

Q Shi, L Qin, W Wei, F Geng, R Fan… - Proceedings of the …, 2012 - National Acad Sciences
We describe a microchip designed to quantify the levels of a dozen cytoplasmic and membrane
proteins from single cells. We use the platform to assess protein–protein interactions …

Spatial-CUT&Tag: spatially resolved chromatin modification profiling at the cellular level

…, G Su, A Enninful, Z Bai, G Castelo-Branco, R Fan - Science, 2022 - science.org
Spatial omics emerged as a new frontier of biological and biomedical research. Here, we
present spatial-CUT&Tag for spatially resolved genome-wide profiling of histone modifications …

[PDF][PDF] LIBLINEAR: A library for large linear classification

RE Fan, KW Chang, CJ Hsieh, XR Wang… - the Journal of machine …, 2008 - jmlr.org
LIBLINEAR is an open source library for large-scale linear classification. It supports logistic
regression and linear support vector machines. We provide easy-to-use command-line tools …

[PDF][PDF] Working set selection using second order information for training support vector machines.

RE Fan, PH Chen, CJ Lin, T Joachims - Journal of machine learning …, 2005 - jmlr.org
Working set selection is an important step in decomposition methods for training support vector
machines (SVMs). This paper develops a new technique for working set selection in SMO…

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

…, RS Paiva, T Ching, C Weaver, X Zi, X Pan, R Fan… - Nature, 2015 - nature.com
Inflammation is a beneficial host response to infection but can contribute to inflammatory
disease if unregulated. The Th17 lineage of T helper (Th) cells can cause severe human …

Block-by-block growth of single-crystalline Si/SiGe superlattice nanowires

Y Wu, R Fan, P Yang - Nano letters, 2002 - ACS Publications
Heterojunction and superlattice formation is essential for many potential applications of
semiconductor nanowires in nanoscale optoelectronics. We have developed a hybrid pulsed …

[HTML][HTML] Spatial profiling of chromatin accessibility in mouse and human tissues

…, KW Leong, M Boldrini, G Castelo-Branco, R Fan - Nature, 2022 - nature.com
Cellular function in tissue is dependent on the local environment, requiring new methods for
spatial mapping of biomolecules and cells in the tissue context 1 . The emergence of spatial …

[HTML][HTML] The technological landscape and applications of single-cell multi-omics

A Baysoy, Z Bai, R Satija, R Fan - Nature Reviews Molecular Cell …, 2023 - nature.com
Single-cell multi-omics technologies and methods characterize cell states and activities by
simultaneously integrating various single-modality omics methods that profile the …