Replacement therapy in hereditary angioedema: successful treatment of acute episodes of angioedema with partly purified C1 inhibitor

JE Gadek, SW Hosea, JA Gelfand… - … England Journal of …, 1980 - Mass Medical Soc
Although considerable progress has been made during the past two decades in the use of
androgens to prevent attacks of hereditary angioedema, replacement of the deficient C1-…

Opsonic requirements for intravascular clearance after splenectomy

SW Hosea, EJ Brown, MI Hamburger… - New England Journal …, 1981 - Mass Medical Soc
We investigated the opsonic requirements for intravascular clearance of pneumococci in
guinea pigs and of sensitized erythrocytes in human beings after splenectomy. The impaired …

The role of antibody and complement in the reticuloendothelial clearance of pneumococci from the bloodstream

EJ Brown, SW Hosea, MM Frank - Reviews of infectious …, 1983 - academic.oup.com
An experimental model of pneumococcal bacteremia in guinea pigs has been developed.
By use of this model, complement has been shown to playa critical role in clearance of …

The role of the spleen in experimental pneumococcal bacteremia.

EJ Brown, SW Hosea, MM Frank - The Journal of clinical …, 1981 - Am Soc Clin Investig
The importance of the spleen in host defense against pneumococcal bacteremia has been
suggested by a number of experimental models as well as the occurrence of the syndrome of …

Long-term therapy of hereditary angioedema with danazol

SW HOSEA, ML SANTAELLA, EJ BROWN… - Annals of internal …, 1980 - acpjournals.org
We treated 69 patients who had hereditary angioedema with danazol to alleviate attacks of
mucocutaneous angioedema involving the skin, oropharynx, and gastrointestinal tract, and …

A quantitative analysis of the interactions of antipneumococcal antibody and complement in experimental pneumococcal bacteremia.

EJ Brown, SW Hosea, CH Hammer… - The Journal of …, 1982 - Am Soc Clin Investig
The mechanism of protection of type-specific antipneumococcal antibody and complement
in bacteremia was investigated with purified rabbit antibody and a guinea pig model of …

Role of complement activation in a model of adult respiratory distress syndrome

S Hosea, E Brown, C Hammer… - The Journal of Clinical …, 1980 - Am Soc Clin Investig
The adult respiratory distress syndrome is characterized by arterial hypoxemia as a result of
increased alveolar capillary permeability to serum proteins in the setting of normal capillary …

The critical role of complement in experimental pneumococcal sepsis

SW Hosea, EJ Brown, MM Frank - Journal of Infectious Diseases, 1980 - academic.oup.com
Using a guinea pig model of bacteremia due to Streptococcus pneumoniae serotype 7,
opsonization by the classical and alternative pathways of complement activation was studied in …

Response of Variant Hereditary Angioedema Phenotypes to Danazol Therapy: GENETIC IMPLICATIONS

JE Gadek, SW Hosea, JA Gelfand… - The Journal of Clinical …, 1979 - Am Soc Clin Investig
Hereditary angioedema (HAE), an auto-somal dominant disorder characterized by attacks
of episodic edema is associated with decreased functional levels of the C1 esterase inhibitor. …

Herpes zoster ophthalmicus in an otherwise-healthy child

NR Binder, GN Holland, S Hosea… - Journal of American …, 2005 - Elsevier
Herpes zoster ophthalmicus, although not uncommon in adults, is rarely found in children.
Herein we present a case of pediatric herpes zoster ophthalmicus that is unique in 2 ways. …