Cystic fibrosis (CF), the most prevalent, fatal genetic disorder in the Caucasian population,
is caused by mutations of CF transmembrane conductance regulator (CFTR). The mutations …

Production of hypochlorous acid (HOCl) in neutrophils, a critical oxidant involved in bacterial
killing, requires chloride anions. Because the primary defect of cystic fibrosis (CF) is the …

In this region it is vulnerable to operations involving mobilization ofthe esophagus, the aortic
arch, and the left subclavian artery. 3 It arches into the superior mediastinum anterolaterally …

Background Acute rejection has emerged as an important risk factor for obliterative bronchiolitis
after lung transplantation. We performed a multivariate analysis to assess the impact of …

Background Although the etiology of idiopathic pulmonary fibrosis (IPF) remains perplexing,
adaptive immune activation is evident among many afflicted patients. Repeated cycles of …

Chloride anion is essential for myeloperoxidase (MPO) to produce hypochlorous acid (HOCl)
in polymorphonuclear neutrophils (PMNs). To define whether chloride availability to PMNs …

Idiopathic pulmonary fibrosis (IPF) is a morbid, refractory lung disorder with an unknown
pathogenesis. To investigate potential adaptive immune mechanisms in IPF, we compared …

Background Severe acute exacerbations (AE) of idiopathic pulmonary fibrosis (IPF) are
medically untreatable and often fatal within days. Recent evidence suggests autoantibodies may …

… Excess erythrocytes were sedimented at 1 g for 30 min at … The leukocyte-rich supernatant
was centrifuged at 300 g for … (density, 1.077 g/ml) and centrifuged at 800 g for 30 min at room …

Background: Obliterative bronchiolitis is a progressive form of obstructive airway disease
that threatens long-term survival in lung transplant recipients. Its incidence and the long-term …