Drug development research in pregnant and lactating women

Z Ren, AA Bremer, AC Pawlyk - American journal of obstetrics and …, 2021 - Elsevier
Pregnant and lactating women are considered “therapeutic orphans” because they
generally have been excluded from clinical drug research and the drug development …

A life-course approach to tackling noncommunicable diseases in women

C Carcel, S Haupt, C Arnott, ML Yap, A Henry… - Nature Medicine, 2024 - nature.com
Women's health has been critically underserved by a failure to look beyond women's sexual
and reproductive systems to adequately consider their broader health needs. In almost …

Sex is a defining feature of neuroimaging phenotypes in major brain disorders

LE Salminen, MA Tubi, J Bright… - Human Brain …, 2022 - Wiley Online Library
Sex is a biological variable that contributes to individual variability in brain structure and
behavior. Neuroimaging studies of population‐based samples have identified normative …

[HTML][HTML] Comprehensive overview of vaccination during pregnancy in Europe

AA Simionescu, A Streinu-Cercel, FD Popescu… - Journal of Personalized …, 2021 - mdpi.com
Vaccinations during pregnancy can protect the mother from several infections, thus blocking
vertical transmission. Furthermore, through passive antibody transfer, the newborn can be …

Pharmacokinetic Evaluation in Pregnancy—Current Status and Future Considerations: Workshop Summary

D Guinn, L Sahin, EP Fletcher, SY Choi… - The Journal of …, 2023 - Wiley Online Library
As pregnant individuals have traditionally been excluded from clinical trials, there is a gap in
knowledge at the time of drug approval regarding safety, efficacy, and appropriate dosing for …

[HTML][HTML] Influence of Liposomes' and Lipoplexes' Physicochemical Characteristics on Their Uptake Rate and Mechanisms by the Placenta

L Fliedel, K Alhareth, J Seguin, M El-Khashab… - International Journal of …, 2022 - mdpi.com
Pregnant women are still considered as drug orphans. Developing new medications for
pregnancy complications is an urgent need. Nanomedicines seem to be a promising …

[HTML][HTML] Safety of drugs and CAM products in pregnancy and breastfeeding: evidence from clinical toxicology

G Crescioli, N Lombardi, A Vannacci - Frontiers in Pharmacology, 2023 - frontiersin.org
Perinatal medicine and pharmacology focus on the wellbeing and health of women and
newborns throughout all stages of pregnancy, from conception to birth, and in the first year of …

Improving Racial and Ethnic Equity in Clinical Trials Enrolling Pregnant and Lactating Individuals

AF Louis‐Jacques, AJ Heuberger… - The Journal of …, 2023 - Wiley Online Library
Racial and ethnic marginalized populations have historically been poorly represented,
underrecruited, and underprioritized across clinical trials enrolling pregnant and lactating …

Haematological changes from conception to childbirth: An indicator of major pregnancy complications

M Patxot, M Stojanov, SE Ojavee… - European Journal of …, 2022 - Wiley Online Library
Background About 800 women die every day worldwide from pregnancy‐related
complications, including excessive blood loss, infections and high‐blood pressure (World …

Lower Extremity Considerations in the Pregnant Patient

AT Black, S Yancovitz, A Rouse… - Foot & Ankle …, 2023 - journals.sagepub.com
There remains a paucity of literature on musculoskeletal dysfunction, biomechanics, and
pathologies of the lower extremity during pregnancy. There are a multitude of physiologic …